Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29574061 | 0.88 | CDK7 (0.46) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL22164627 | 0.88 | LMNA (0.41) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL28738717 | 0.87 | P2RY14 (0.41) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL25947657 | 0.85 | CDK7 (0.38) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL25947656 | 0.79 | CDK2 (0.59) | CCNA2CDK2CCNA1NTRK1 | |
| SCHEMBL17872102 | 0.78 | KMT2A (0.44) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL25951333 | 0.78 | LMNA (0.42) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL17872158 | 0.78 | KMT2A (0.43) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL17872086 | 0.78 | MAPT (0.40) | NPC1RAB9ACDK7CCNHMNAT1 | |
| SCHEMBL25947645 | 0.77 | PAK4 (0.58) | CDK7CCNHMNAT1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003335-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114401719-A | Inhibitors of cyclin-dependent kinase 7 and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2022-04-26 | — | — | CN | disclosed |