Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29575713 | 0.83 | NEK2 (0.53) | LMNAHTTKDM4EALDH1A1 | |
| SCHEMBL30748580 | 0.77 | GRM4 (0.41) | PDE10AGSK3AGSK3BPIK3CAMTOR | |
| SCHEMBL31219553 | 0.70 | PRKD1 (0.40) | PRKD1MAPTPDE10ACDK1CDK2 | |
| SCHEMBL30527140 | 0.70 | KDM4A (0.46) | MAPTLMNAHTTPDE10AEGFR | |
| SCHEMBL31553912 | 0.69 | MAPT (0.48) | PRKD1MAPTPDE10AJAK2EGFR | |
| SCHEMBL15205768 | 0.69 | PLG (0.43) | PRKD1HTTPDE10ACDK1CDK2 | |
| SCHEMBL29699634 | 0.68 | SORD (0.53) | MAPTLMNAHTTROCK1JAK2 | |
| SCHEMBL17208274 | 0.68 | SORD (0.53) | MAPTLMNAHTTROCK1JAK2 | |
| SCHEMBL21855948 | 0.67 | PDE10A (0.41) | LMNAHTTPDE10AAURKACDK1 | |
| SCHEMBL21856104 | 0.67 | MAPK12 (0.42) | LMNAHTTPDE10AAURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036012-B | Pyrido [3,4-d ] pyrimidine derivatives and pharmaceutically acceptable salts thereof | 帝人制药株式会社 | 2022-05-10 | — | — | CN | claimed |
| CN-110036012-B | Pyrido [3,4-d ] pyrimidine derivatives and pharmaceutically acceptable salts thereof | 帝人制药株式会社 | 2022-05-10 | — | — | CN | disclosed |