Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.49 |
| ▸ | EMG1 | Q92979 | 2/20 | 0.49 |
| ▸ | MME | P08473 | 17/20 | 0.46 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929821 | 0.96 | ACE (0.51) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9930175 | 0.88 | ACE (0.51) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9930434 | 0.88 | ACE (0.53) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9929802 | 0.88 | ACE (0.59) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9930147 | 0.85 | ACE (0.65) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9937332 | 0.85 | ACE (0.65) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9929635 | 0.82 | ACE (0.59) | ACEEMG1MME | |
| SCHEMBL9929753 | 0.79 | MME (0.53) | ACEMMEMMEL1 | |
| SCHEMBL9941348 | 0.79 | MME (0.53) | ACEMMEMMEL1 | |
| SCHEMBL9930046 | 0.78 | ACE (0.69) | ACEEMG1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11851443-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-12-26 | — | — | US | disclosed |
| US-20220298173-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-09-22 | — | — | US | disclosed |
| US-11261197-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261197-B2 | Neprilysin inhibitors | MME, REN, ACE | ACE 3/4885EMG1 1982/4885MME 1/4885 |
| US-20220298173-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | ACE 3/4885EMG1 2092/4885MME 1/4885 |
| US-11851443-B2 | Neprilysin inhibitors | MME, REN, ACE | ACE 3/4885EMG1 1982/4885MME 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.