Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11279342 | 0.83 | ALDH1A1 (0.44) | CASP3TTRCES1ALDH1A1CYP1A2 | |
| SCHEMBL11486350 | 0.79 | ALDH1A1 (0.55) | ALDH1A1CYP1A2SMN1; SMN2AKT1 | |
| SCHEMBL24334888 | 0.78 | CASP3 (0.38) | CASP3TTRCES1ALDH1A1CYP1A2 | |
| SCHEMBL29531391 | 0.74 | MAPK7 (0.49) | CASP3TTRCES1TNK2TRPA1 | |
| SCHEMBL19496540 | 0.74 | MAPK7 (0.49) | CASP3TTRCES1TNK2TRPA1 | |
| SCHEMBL7982510 | 0.73 | TTR (0.55) | CASP3TTRCES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20875235 | 0.73 | PDGFRA (0.55) | ALDH1A1CYP1A2SMN1; SMN2GSK3BALOX15 | |
| Hydrochloric Acid SCHEMBL29530065 | 0.72 | MAPK7 (0.48) | CASP3TTRCES1TNK2TRPA1 | |
| SCHEMBL16980134 | 0.71 | POLB (0.39) | CASP3TTRCES1ALDH1A1CYP1A2 | |
| SCHEMBL5937266 | 0.71 | ALDH1A1 (0.66) | TTRCES1ALDH1A1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229061-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | Ranok Therapeutics (Hangzhou) Co. Ltd. (CN) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022078350-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |