Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 10/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24423144 | 1.00 | TBK1 (0.33) | TBK1LRRK2KDM5AOPRM1OPRL1 | |
| SCHEMBL24424274 | 0.92 | LRRK2 (0.37) | TBK1LRRK2KDM5APDK1PDK2 | |
| SCHEMBL29584713 | 0.92 | LRRK2 (0.37) | TBK1LRRK2KDM5APDK1PDK2 | |
| SCHEMBL29584774 | 0.91 | KDM4E (0.33) | TBK1LRRK2KDM5APDK1PDK2 | |
| SCHEMBL25090753 | 0.91 | KDM4E (0.33) | TBK1LRRK2KDM5APDK1PDK2 | |
| SCHEMBL24424720 | 0.90 | LRRK2 (0.32) | LRRK2KDM5AJAK2JAK3SMN1; SMN2 | |
| SCHEMBL24424718 | 0.90 | LRRK2 (0.32) | LRRK2KDM5AJAK2JAK3SMN1; SMN2 | |
| SCHEMBL24424721 | 0.90 | LRRK2 (0.32) | LRRK2KDM5AJAK2JAK3SMN1; SMN2 | |
| SCHEMBL25090732 | 0.87 | KDM5A (0.34) | KDM5AHPGDHSD17B10 | |
| SCHEMBL24424249 | 0.86 | KDM5A (0.32) | KDM5APDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |