Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 4/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25090753 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1HSD17B10LRRK2TBK1 | |
| SCHEMBL24424274 | 0.92 | LRRK2 (0.37) | LRRK2TBK1KDM5APDK1PDK2 | |
| SCHEMBL29584713 | 0.92 | LRRK2 (0.37) | LRRK2TBK1KDM5APDK1PDK2 | |
| SCHEMBL29584692 | 0.91 | TBK1 (0.33) | KDM4EHSD17B10LRRK2TBK1KDM5A | |
| SCHEMBL24423144 | 0.91 | TBK1 (0.33) | KDM4EHSD17B10LRRK2TBK1KDM5A | |
| SCHEMBL24424439 | 0.88 | KDM5A (0.32) | ALDH1A1HSD17B10LRRK2KDM5A | |
| SCHEMBL29585253 | 0.88 | KDM5A (0.32) | ALDH1A1HSD17B10LRRK2KDM5A | |
| SCHEMBL24424249 | 0.86 | KDM5A (0.32) | KDM5APDK1PDK2PDK3PDK4 | |
| SCHEMBL25090732 | 0.84 | KDM5A (0.34) | ALDH1A1HSD17B10KDM5AHPGD | |
| SCHEMBL24424040 | 0.83 | FFAR4 (0.37) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |