Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27171156 | 1.00 | EGLN2 (0.47) | EGLN2KDM4EALDH1A1GAANAMPT | |
| SCHEMBL27171158 | 1.00 | EGLN2 (0.47) | EGLN2KDM4EALDH1A1GAANAMPT | |
| SCHEMBL5881677 | 0.85 | KDM4E (0.53) | EGLN2KDM4EALDH1A1GAATTK | |
| SCHEMBL4464361 | 0.81 | KDM4E (0.49) | EGLN2KDM4EALDH1A1GAANAMPT | |
| SCHEMBL29585713 | 0.81 | KAT2B (0.53) | EGLN2NAMPTNSD2VNN1 | |
| SCHEMBL27171094 | 0.81 | KAT2B (0.53) | EGLN2NAMPTNSD2VNN1 | |
| SCHEMBL27171091 | 0.81 | KAT2B (0.53) | EGLN2NAMPTNSD2VNN1 | |
| SCHEMBL24306243 | 0.80 | ALDH1A1 (0.48) | EGLN2KDM4EALDH1A1GAANAMPT | |
| SCHEMBL29586014 | 0.80 | ALDH1A1 (0.48) | EGLN2KDM4EALDH1A1GAANAMPT | |
| SCHEMBL26914375 | 0.80 | ALDH1A1 (0.48) | EGLN2KDM4EALDH1A1GAANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229049-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-116547278-A | Heterocyclic GLP-1 agonists | 加舒布鲁姆生物公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022078380-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-04-21 | — | — | WO | disclosed |