Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464361 | 0.93 | KDM4E (0.49) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL4243128 | 0.88 | KDM4E (0.42) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL31200412 | 0.85 | PTGER4 (0.51) | KDM4EALDH1A1GAAPTGER4JAK2 | |
| SCHEMBL27171156 | 0.85 | EGLN2 (0.47) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL27171158 | 0.85 | EGLN2 (0.47) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL29585778 | 0.85 | EGLN2 (0.47) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL24306243 | 0.82 | ALDH1A1 (0.48) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL29586014 | 0.82 | ALDH1A1 (0.48) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL26914375 | 0.82 | ALDH1A1 (0.48) | KDM4EALDH1A1GAAPTGER4EGLN2 | |
| SCHEMBL3054224 | 0.78 | CNR2 (0.52) | EGLN2JAK2JAK1TYK2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135554-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | US | disclosed |
| US-7030139-B2 | Compounds | ASTRAZENECA AB (SE) | 2006-04-18 | — | — | US | disclosed |
| CN-1250531-C | Novel compounds | ASTRAZENECA AB (SE) | 2006-04-12 | — | — | CN | disclosed |
| US-20040116465-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |
| CN-1503787-A | Novel compounds | — | 2004-06-09 | — | — | CN | disclosed |
| EP-1390350-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002085866-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135554-A1 | Novel compounds | OPRL1, OPRK1, TRPV1 | KDM4E 4683/4885ALDH1A1 1314/4885GAA 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.