Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 2/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959357 | 0.87 | MAP3K14 (0.48) | PTGDR2PTGS2NR1H2NR1H3HTR2A | |
| SCHEMBL2955003 | 0.85 | MAPK14 (0.47) | PTGDR2PTGS2HTR2AHTR2CHTR7 | |
| SCHEMBL2961347 | 0.83 | PTGDR2 (0.44) | PTGDR2NR1H2NR1H3HTR2AHTR2C | |
| SCHEMBL2961945 | 0.82 | NR1H2 (0.47) | PTGDR2PTGS2NR1H2NR1H3HTR2A | |
| SCHEMBL2958277 | 0.77 | NR1H2 (0.44) | PTGDR2PTGS2NR1H2NR1H3RXRA | |
| SCHEMBL2961361 | 0.76 | NR1H2 (0.62) | PTGDR2NR1H2NR1H3RXRA | |
| SCHEMBL317159 | 0.76 | NR1H2 (0.55) | PTGDR2PTGS2NR1H2NR1H3COMT | |
| SCHEMBL317746 | 0.75 | PTGDR2 (0.53) | PTGDR2PTGS2GSK3AGSK3BFLT3 | |
| SCHEMBL317919 | 0.75 | PTGDR2 (0.84) | PTGDR2PTGS2 | |
| SCHEMBL2951882 | 0.73 | KIF11 (0.49) | PTGDR2PTGS2HTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210685-A1 | Novel Substituted Indoles | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | US | disclosed |
| US-7754735-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2010-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210685-A1 | Novel Substituted Indoles | IDO1, IDO2, TPH1 | PTGDR2 429/4885PTGS2 559/4885NR1H2 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.