Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PARL | Q9H300 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799652 | 0.87 | HTR6 (0.67) | HTR6PKMHDAC6PARLTUBB4A | |
| SCHEMBL10467679 | 0.83 | HTR6 (0.66) | HTR6PKMHDAC6PARLTUBB4A | |
| SCHEMBL21219238 | 0.82 | HTR6 (0.44) | HTR6PKMLOXL2KMT2AALDH1A1 | |
| SCHEMBL5036587 | 0.80 | HTR6 (0.58) | HTR6PKMHDAC6PARLTUBB4A | |
| SCHEMBL7128590 | 0.79 | HTR6 (0.57) | HTR6PKMHDAC6PARLTUBB4A | |
| SCHEMBL1647468 | 0.77 | PKM (0.56) | HTR6PKMHDAC6PARLTUBB4A | |
| Fumaric Acid SCHEMBL28821775 | 0.77 | KDM4E (0.41) | HTR6PKMALDH1A1HPGDTSHR | |
| SCHEMBL16111028 | 0.76 | HTR6 (0.66) | HTR6PKMHDAC6TUBB4ATUBB | |
| SCHEMBL8800158 | 0.76 | HTR6 (0.66) | HTR6PKMHDAC6TUBB4ATUBB | |
| SCHEMBL752913 | 0.76 | HTR6 (0.55) | HTR6PKMHDAC6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478528-A | Aroyl-substituted tricyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2022-05-13 | — | — | CN | disclosed |