Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22835026 | 1.00 | MAPK8 (0.40) | MAPK8KDM4EALDH1A1GLAGAA | |
| SCHEMBL28721952 | 0.97 | OPRK1 (0.40) | MAPK8KDM4EALDH1A1GLAGAA | |
| SCHEMBL31003980 | 0.85 | TYK2 (0.37) | MAPK8TYK2HSD11B1 | |
| SCHEMBL22834749 | 0.85 | TYK2 (0.37) | MAPK8TYK2HSD11B1 | |
| SCHEMBL22835196 | 0.83 | HSP90AA1 (0.54) | KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL29652040 | 0.83 | HSP90AA1 (0.54) | KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL10995234 | 0.79 | TSHR (0.45) | KDM4EALDH1A1GLAGAATSHR | |
| SCHEMBL22835084 | 0.76 | TRPC6 (0.47) | MAPK8KDM4EALDH1A1GLAGAA | |
| SCHEMBL29598236 | 0.76 | TRPC6 (0.47) | MAPK8KDM4EALDH1A1GLAGAA | |
| SCHEMBL22834905 | 0.75 | NPC1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140425-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE | BIOGEN MA INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| EP-3990454-A1 | IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Biogen MA Inc. (US) | 2022-05-04 | — | — | EP | disclosed |