SCHEMBL29600409

SCHEMBL29600409

COC(=O)c1ccc2c(c1)CCCC(Br)=C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.41
CA9 Q16790 2/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
XDH P47989 1/20 0.41
CA14 Q9ULX7 1/20 0.41
NOTUM Q6P988 1/20 0.41
TRPA1 O75762 3/20 0.40
PDK1 Q15118 1/20 0.40
PDK2 Q15119 1/20 0.40
PDK3 Q15120 1/20 0.40
PDK4 Q16654 1/20 0.40
HDAC1 Q13547 1/20 0.39
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 3/20 0.39
MAPT P10636 3/20 0.39
HPGD P15428 3/20 0.39
HSD17B10 Q99714 3/20 0.39
ATM Q13315 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL883530 0.78 ALDH1A1 (0.61) CA12CA9CA1CA2CA7
SCHEMBL10247077 0.78 SRD5A1 (0.46) CA12CA9CA1CA2CA7
SCHEMBL25107063 0.77 CA1 (0.44) CA12CA9CA1CA2CA7
SCHEMBL29521291 0.75 CA1 (0.42) CA12CA9CA1CA2CA7
SCHEMBL29562345 0.75 CA1 (0.42) CA12CA9CA1CA2CA7
SCHEMBL31544703 0.75 ALDH1A1 (0.56) CA12CA9CA1CA2CA7
SCHEMBL2633409 0.75 ALDH1A1 (0.56) CA12CA9CA1CA2CA7
Bromide SCHEMBL29520859 0.74 CA1 (0.41) CA12CA9CA1CA2CA7
SCHEMBL24428996 0.74 MAPT (0.43) CA12CA9ALDH1A1MAPTATM
SCHEMBL30648924 0.74 MAPT (0.43) CA12CA9ALDH1A1MAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4228758-A1 SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF Sanofi (FR) 2023-08-23 EP disclosed
WO-2022084280-A1 SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF SANOFI (FR) 2022-04-28 WO disclosed