Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039792 | 1.00 | CACNA1I (0.45) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL21078914 | 0.89 | P4HTM (0.41) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL19992569 | 0.88 | BACE1 (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL287075 | 0.85 | P4HTM (0.58) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL286756 | 0.84 | MAPK1 (0.53) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL21920979 | 0.84 | CACNA1I (0.40) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL15994885 | 0.84 | KMT2A (0.58) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL15991475 | 0.83 | ALDH1A1 (0.57) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL21078924 | 0.83 | CACNA1G (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2140228 | 0.82 | NPC1 (0.50) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |