Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039782 | 1.00 | GRM5 (0.44) | GRM5NPC1RAB9ASMN1; SMN2CSF1R | |
| SCHEMBL29078712 | 0.85 | EGLN1 (0.47) | GRM5NPC1RAB9ACSF1RFLT3 | |
| SCHEMBL29601242 | 0.85 | EGLN1 (0.47) | GRM5NPC1RAB9ACSF1RFLT3 | |
| SCHEMBL29601352 | 0.79 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL27039815 | 0.79 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL29601359 | 0.79 | GRM5 (0.47) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27039798 | 0.77 | GRM5 (0.42) | GRM5CSF1RFLT3PDGFRBKIT | |
| SCHEMBL29601311 | 0.77 | MAPK1 (0.48) | GRM5CSF1RFLT3EPHX2 | |
| SCHEMBL29601804 | 0.75 | KDM4E (0.47) | GRM5SMN1; SMN2CSF1RFLT3GLA | |
| SCHEMBL29078774 | 0.75 | KDM4E (0.47) | GRM5SMN1; SMN2CSF1RFLT3GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |