Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190351 | 1.00 | GSK3B (0.58) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| Bromide SCHEMBL29938709 | 0.98 | GSK3B (0.57) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| Bromide SCHEMBL15993360 | 0.98 | GSK3B (0.57) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL27196361 | 0.83 | GSK3B (0.51) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL19782876 | 0.81 | GSK3B (0.54) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL19782386 | 0.79 | GSK3B (0.51) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL19782990 | 0.78 | BRD4 (0.45) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| SCHEMBL19782864 | 0.78 | GSK3B (0.57) | GSK3BKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL29601629 | 0.78 | GSK3B (0.66) | GSK3BKMT2ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL15993270 | 0.78 | GSK3B (0.66) | GSK3BKMT2ASMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |