Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.70 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.70 |
| ▸ | PTPRB | P23467 | 1/20 | 0.70 |
| ▸ | PTPRE | P23469 | 1/20 | 0.70 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.64 |
| ▸ | RAB7A | P51149 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 8/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453432 | 0.83 | PTPN1 (0.71) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL4312414 | 0.82 | PTPN1 (1.00) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL5741314 | 0.82 | PTPN1 (0.75) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL20541702 | 0.81 | KDM4E (0.77) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL4090461 | 0.81 | CNR2 (0.70) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL20541804 | 0.80 | FLT3 (0.75) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL4141589 | 0.79 | PTPRC (0.70) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL20541770 | 0.79 | ANO1 (1.00) | ANO1CNR2KIF11CFTRCNR1 | |
| SCHEMBL3760411 | 0.77 | PTPN1 (0.67) | PTPRCPTPN2PTPN1PTPRBPTPRE | |
| SCHEMBL5451710 | 0.77 | CFTR (0.58) | PTPRCPTPN2PTPN1PTPRBPTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358947-B2 | Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358947-B2 | Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A | TMEM161A, ANO2, TRPV6 | PTPRC 1726/4885PTPN2 3627/4885PTPN1 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.