ANO2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4147839	0.79	5/20
SCHEMBL4135518	0.76	5/20
SCHEMBL4150336	0.68	4/20
SCHEMBL6435397	0.47	4/20
SCHEMBL4139983	0.77	3/20
SCHEMBL4145647	0.77	3/20
SCHEMBL4148960	0.75	3/20
SCHEMBL4139676	0.73	3/20
SCHEMBL4140424	0.71	3/20
SCHEMBL4134815	0.69	3/20
SCHEMBL4134799	0.81	2/20
SCHEMBL4151223	0.81	2/20
SCHEMBL4136619	0.80	2/20
SCHEMBL4147246	0.79	2/20
SCHEMBL4140756	0.77	2/20
SCHEMBL4145029	0.77	2/20
SCHEMBL4153255	0.77	2/20
SCHEMBL4141379	0.75	2/20
SCHEMBL4132190	0.70	2/20
SCHEMBL4140828	0.70	2/20

Clinical trials — most relevant to ANO2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
4-Aminopyridine in Episodic Ataxia Type 2	PHASE2	WITHDRAWN
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.	PHASE2	NOT_YET_RECRUITING
The Response To Ajmaline Provocation in Healthy Subjects	PHASE2	UNKNOWN
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants	nan	RECRUITING
3 Year Follow up on ANO5 Patients	nan	ACTIVE_NOT_RECRUITING
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Piezo2-related Arthrogryposis & physiopathOLOgy 3	nan	NOT_YET_RECRUITING
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Multidisciplinary Study of Right Ventricular Dysplasia	nan	COMPLETED
The Genetic Basis of Atrial Fibrillation (AF)	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Feasibility of Improving Risk Stratification in Brugada Syndrome	nan	COMPLETED
Families' Experiences of Paediatric ICC Diagnosis	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)	nan	RECRUITING
Painful Channelopathies Study	nan	UNKNOWN
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease	nan	COMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis	nan	UNKNOWN
Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders	nan	RECRUITING
Early PKD Observational Cohort Study	nan	RECRUITING
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene	nan	RECRUITING
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
New Biomarkers and Difficult-to-treat Hypertension	nan	COMPLETED
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis	nan	RECRUITING
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ANO2 binder may also engage these)

Protein	Name	Similarity
Q8CFW1	—	0.998	Q8CFW1 →
Q7TQ69	—	0.997	Q7TQ69 →
Q8BHY3	—	0.997	Q8BHY3 →
Q14AT5	—	0.995	Q14AT5 →
Q11069	—	0.994	Q11069 →
Q0JJZ6	—	0.993	Q0JJZ6 →
ANO1	Anoctamin-1	0.992	landscape →
Q5YCC7	—	0.992	Q5YCC7 →
Q75UR0	—	0.992	Q75UR0 →
Q75V66	—	0.992	Q75V66 →
TRPC1	Short transient receptor potential channel 1	0.991	landscape →
Q9QX29	—	0.991	Q9QX29 →
Q9FKY5	—	0.991	Q9FKY5 →
Q6IWH7	—	0.990	Q6IWH7 →
P93766	—	0.990	P93766 →
Q6P9J9	—	0.990	Q6P9J9 →
P19334	—	0.989	P19334 →
Q7T047	—	0.989	Q7T047 →
O35119	—	0.989	O35119 →
Q61056	—	0.989	Q61056 →
Q7Z5M5	—	0.988	Q7Z5M5 →
D3KZG3	—	0.988	D3KZG3 →
Q6IFT6	—	0.988	Q6IFT6 →
TRPC4	Short transient receptor potential channel 4	0.988	landscape →
P48994	—	0.988	P48994 →
Q02739	—	0.988	Q02739 →
P18860	—	0.988	P18860 →
Q4KMQ2	—	0.988	Q4KMQ2 →
P51914	—	0.988	P51914 →
Q21123	—	0.988	Q21123 →