Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 16/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039803 | 1.00 | DHODH (0.50) | DHODHMAPTNPSR1KDM4ELMNA | |
| SCHEMBL27039800 | 0.86 | DHODH (0.53) | DHODHMAPTNPSR1KDM4ELMNA | |
| SCHEMBL19782992 | 0.85 | DHODH (0.56) | DHODHMAPTNPSR1KDM4EMEN1 | |
| SCHEMBL19782985 | 0.83 | DHODH (0.51) | DHODHMAPTNPSR1KDM4ELMNA | |
| SCHEMBL27039903 | 0.81 | KCNN1 (0.44) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL29601231 | 0.81 | KCNN1 (0.44) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL19783118 | 0.79 | DHODH (0.48) | DHODHMAPTNPSR1KDM4EMEN1 | |
| SCHEMBL15993448 | 0.78 | DHODH (0.53) | DHODHMAPTNPSR1KDM4ELMNA | |
| SCHEMBL19782993 | 0.78 | DHODH (0.47) | DHODHMAPTNPSR1KDM4EMEN1 | |
| SCHEMBL24358082 | 0.77 | KCNN1 (0.42) | MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |