Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635267 | 1.00 | UCHL1 (0.31) | UCHL1PRMT5WDR77MDM2KDM4E | |
| SCHEMBL19615953 | 0.91 | PRMT5 (0.32) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL29601766 | 0.86 | KDM4E (0.33) | UCHL1KDM4EALDH1A1HPGD | |
| SCHEMBL19635012 | 0.86 | KDM4E (0.33) | UCHL1KDM4EALDH1A1HPGD | |
| SCHEMBL21802166 | 0.84 | HTR6 (0.35) | UCHL1PRMT5WDR77ALDH1A1 | |
| SCHEMBL29601778 | 0.80 | MCL1 (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL19635268 | 0.80 | MCL1 (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL22437338 | 0.76 | HTR6 (0.35) | UCHL1ALDH1A1 | |
| SCHEMBL22436710 | 0.76 | HTR6 (0.34) | UCHL1ALDH1A1 | |
| SCHEMBL21802248 | 0.75 | MCL1 (0.30) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | THE BROAD INSTITUTE, INC. (US) | 2022-11-08 | — | — | US | disclosed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | CCND2, CCNT2, IDO1 | UCHL1 3420/4885PRMT5 168/4885WDR77 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.