Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202399 | 0.85 | AAK1 (0.43) | AAK1LCKSYKRORCNPC1 | |
| SCHEMBL29360815 | 0.85 | AAK1 (0.43) | AAK1LCKSYKRORCNPC1 | |
| SCHEMBL24366932 | 0.84 | LMNA (0.40) | AAK1LMNAPOLBARCACNA1H | |
| SCHEMBL29477586 | 0.84 | LMNA (0.40) | AAK1LMNAPOLBARCACNA1H | |
| SCHEMBL2960307 | 0.83 | AAK1 (0.43) | AAK1LCKSYKRORCNPC1 | |
| SCHEMBL1181471 | 0.82 | AAK1 (0.51) | AAK1LCKRORCNPC1RECQL | |
| SCHEMBL2404084 | 0.81 | ALDH1A1 (0.39) | SSTR4SMN1; SMN2KDR | |
| SCHEMBL858165 | 0.81 | AAK1 (0.42) | AAK1LCKRORCNPC1RECQL | |
| SCHEMBL17310500 | 0.80 | ASPH (0.38) | LMNASSTR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29081695 | 0.80 | ALDH1A1 (0.49) | LMNAPOLBARNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2912037-B1 | 2-AMINOPYRIDINE COMPOUNDS | MERCK PATENT GMBH (DE) | 2018-08-22 | — | — | EP | disclosed |
| US-9834541-B2 | 2-aminopyridine compounds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-12-05 | — | — | US | disclosed |
| US-9834541-B2 | 2-aminopyridine compounds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-12-05 | — | — | US | disclosed |
| US-20150353548-A1 | 2-AMINOPYRIDINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-12-10 | — | — | US | disclosed |
| US-20150353548-A1 | 2-AMINOPYRIDINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-12-10 | — | — | US | disclosed |
| EP-2912037-A1 | 2-AMINOPYRIDINE COMPOUNDS | Merck Patent GmbH (DE) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014063778-A1 | 2-AMINOPYRIDINE COMPOUNDS | MERCK PATENT GMBH (DE) | 2014-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353548-A1 | 2-AMINOPYRIDINE COMPOUNDS | SKP2, CDKN1A, MKI67 | AAK1 294/4885LMNA 2152/4885POLB 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.