Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27133505 | 1.00 | PTGDR2 (0.42) | PTGDR2PTPN11CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26969411 | 0.88 | PTGDR2 (0.40) | PTGDR2KDM4ELMNATSHRL3MBTL1 | |
| SCHEMBL19320363 | 0.81 | PTGDR2 (0.39) | PTGDR2TSHRL3MBTL1LATS1MEN1 | |
| SCHEMBL29605086 | 0.79 | PTGDR2 (0.54) | PTGDR2L3MBTL1CCKARLATS1 | |
| SCHEMBL20576447 | 0.74 | AGTR1 (0.39) | PTGDR2PTPN11CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4616627 | 0.74 | PTGDR2 (0.55) | PTGDR2CYP2C19CCKARLATS1 | |
| SCHEMBL20575807 | 0.73 | MAPK14 (0.39) | PTGDR2PTPN11LMNA | |
| SCHEMBL30321193 | 0.73 | MAPK14 (0.39) | PTGDR2PTPN11LMNA | |
| SCHEMBL30946368 | 0.72 | PKM (0.40) | LMNATSHRL3MBTL1MEN1POLB | |
| SCHEMBL30946361 | 0.72 | PKM (0.40) | LMNATSHRL3MBTL1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |