Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23120739 | 1.00 | GLA (0.39) | GLAKMT2ACRBNNR3C1PGR | |
| SCHEMBL23121068 | 0.90 | EPHX2 (0.41) | GLAKMT2ACRBNNR3C1PGR | |
| SCHEMBL30995363 | 0.88 | CRBN (0.41) | CRBNCHRM2CHRM3JAK1EPHX2 | |
| SCHEMBL29607702 | 0.87 | JAK1 (0.39) | GLAKMT2ACRBNNR3C1PGR | |
| SCHEMBL23121080 | 0.87 | JAK1 (0.39) | GLAKMT2ACRBNNR3C1PGR | |
| SCHEMBL21409353 | 0.85 | NR3C1 (0.41) | CRBNNR3C1PGRSLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL31138071 | 0.84 | NR3C1 (0.41) | CRBNNR3C1PGRSLC6A4KCNH2 | |
| SCHEMBL24735010 | 0.84 | NR3C1 (0.47) | GLAKMT2ANR3C1PGRSLC6A4 | |
| SCHEMBL29841507 | 0.84 | NR3C1 (0.47) | GLAKMT2ANR3C1PGRSLC6A4 | |
| SCHEMBL31255399 | 0.84 | CYP3A4 (0.45) | NR3C1PGRSLC6A4KCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031247-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | Novartis AG (CH) | 2022-07-27 | — | — | EP | disclosed |
| CN-114521196-A | Bifunctional group degradation agent and use method thereof | 诺华股份有限公司 | 2022-05-20 | — | — | CN | disclosed |