Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23390111 | 1.00 | PIM1 (0.38) | PIM1PTGS1PTGS2SMN1; SMN2EGLN1 | |
| SCHEMBL23390113 | 1.00 | PIM1 (0.38) | PIM1PTGS1PTGS2SMN1; SMN2EGLN1 | |
| SCHEMBL23390259 | 0.92 | EGLN1 (0.40) | PIM1PTGS1PTGS2SMN1; SMN2EGLN1 | |
| SCHEMBL30101937 | 0.92 | EGLN1 (0.40) | PIM1PTGS1PTGS2SMN1; SMN2EGLN1 | |
| SCHEMBL23390257 | 0.92 | EGLN1 (0.40) | PIM1PTGS1PTGS2SMN1; SMN2EGLN1 | |
| SCHEMBL29610251 | 0.88 | TRPV3 (0.36) | SYKTRPV3PTGESALDH1A1 | |
| SCHEMBL23390196 | 0.88 | TRPV3 (0.36) | SYKTRPV3PTGESALDH1A1 | |
| SCHEMBL23390198 | 0.88 | TRPV3 (0.36) | SYKTRPV3PTGESALDH1A1 | |
| SCHEMBL23390289 | 0.88 | CYP2A6 (0.44) | PIM1PTGS1PTGS2EGLN1 | |
| SCHEMBL23390292 | 0.88 | CYP2A6 (0.44) | PIM1PTGS1PTGS2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115397512-B | As AHR antagonists Pyridopyrimidinone derivatives | 先达生物科技公司 | 2024-12-17 | — | — | CN | claimed |
| CN-115397512-A | Pyridopyrimidinone derivatives as AHR antagonists | 先达生物科技公司 | 2022-11-25 | — | — | CN | claimed |
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | claimed |
| CN-115397512-B | As AHR antagonists Pyridopyrimidinone derivatives | 先达生物科技公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-116745622-A | Biomarkers related to immune checkpoint inhibitor therapies and methods of use thereof | 先达生物科技公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-4228649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | Senda Biosciences, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-115397512-A | Pyridopyrimidinone derivatives as AHR antagonists | 先达生物科技公司 | 2022-11-25 | — | — | CN | disclosed |
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | disclosed |
| WO-2022081649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | SENDA BIOSCIENCES, INC. (US) | 2022-04-21 | — | — | WO | disclosed |