Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.53 |
| ▸ | GRM5 | P41594 | 9/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30919589 | 0.89 | TNK2 (0.48) | GRM1GRM5TNK2PDE10APDK4 | |
| SCHEMBL15942450 | 0.86 | GRM1 (0.50) | GRM1GRM5TNK2PDE10APDK4 | |
| SCHEMBL30513849 | 0.83 | GRM1 (0.54) | GRM1GRM5TNK2PDE10APDK4 | |
| SCHEMBL31583898 | 0.83 | GRM1 (0.55) | GRM1GRM5TNK2CDK9PDE10A | |
| SCHEMBL30919924 | 0.83 | DGAT2 (0.39) | GRM1GRM5CDK9GPR119 | |
| SCHEMBL31640027 | 0.82 | PDK4 (0.52) | GRM1GRM5TNK2PDK4 | |
| SCHEMBL13275649 | 0.82 | CYP11B2 (0.54) | GRM1GRM5TNK2PDK4GPR119 | |
| SCHEMBL29611478 | 0.80 | GRM5 (0.51) | GRM1GRM5TNK2CDK9PDE10A | |
| SCHEMBL22328950 | 0.80 | GRM1 (0.57) | GRM1GRM5TNK2CDK9PDE10A | |
| SCHEMBL25119907 | 0.79 | GRM1 (0.54) | GRM1GRM5TNK2CDK9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022051565-A1 | SUBSTITUTED 4-PIPERIDINYL-QUINAZOLINES, 4-PIPERIDINYL-PYRIMIDINE-2-AMINES, AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-03-10 | — | — | WO | disclosed |