Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 6/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | ESRRB | O95718 | 1/20 | 0.31 |
| ▸ | ESRRA | P11474 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23042585 | 1.00 | NPC1 (0.36) | NPC1MAPTESR1ESR2F2RL1 | |
| SCHEMBL29612550 | 0.85 | DGAT1 (0.42) | NPC1MAPTF2RL1DGAT1ELANE | |
| SCHEMBL28730648 | 0.85 | DGAT1 (0.42) | NPC1MAPTF2RL1DGAT1ELANE | |
| SCHEMBL19023399 | 0.85 | NPC1 (0.38) | NPC1MAPTESR1ESR2DGAT1 | |
| SCHEMBL29612533 | 0.85 | NPC1 (0.38) | NPC1MAPTESR1ESR2DGAT1 | |
| SCHEMBL28939042 | 0.82 | NPC1 (0.36) | NPC1MAPTESR1ESR2DGAT1 | |
| SCHEMBL30459885 | 0.82 | DGAT1 (0.34) | NPC1DGAT1 | |
| SCHEMBL17682976 | 0.82 | DGAT1 (0.34) | NPC1DGAT1 | |
| SCHEMBL5988574 | 0.81 | MCL1 (0.41) | NPC1MAPTELANEGAATSHR | |
| SCHEMBL1572528 | 0.79 | ELANE (0.52) | MAPTALOX15ELANEGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |