Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23063015 | 1.00 | PPARG (0.56) | PPARGCYP3A4ALDH1A1MAPTATM | |
| SCHEMBL23063011 | 0.87 | PPARG (0.56) | PPARGCYP3A4ALDH1A1MAPTATM | |
| SCHEMBL9800640 | 0.83 | MAPT (0.58) | PPARGCYP3A4ALDH1A1MAPTATM | |
| SCHEMBL3821627 | 0.82 | ALDH1A1 (0.49) | PPARGCYP3A4ALDH1A1MAPTATM | |
| SCHEMBL633564 | 0.81 | PPARG (0.58) | PPARGCYP3A4 | |
| SCHEMBL9800721 | 0.80 | ALDH1A1 (0.66) | CYP3A4ALDH1A1MAPTATMKDM4E | |
| SCHEMBL29612551 | 0.80 | PPARG (0.53) | PPARGCYP3A4ALDH1A1MAPTKDM4E | |
| SCHEMBL28730677 | 0.80 | PPARG (0.53) | PPARGCYP3A4ALDH1A1MAPTKDM4E | |
| SCHEMBL11292862 | 0.80 | HTT (0.53) | PPARGCYP3A4ALDH1A1MAPTKDM4E | |
| SCHEMBL17164822 | 0.79 | NPC1 (0.61) | PPARGCYP3A4ALDH1A1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |