Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 9/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19836331 | 1.00 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL29827536 | 0.83 | IRAK4 (0.44) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL19836464 | 0.83 | IRAK4 (0.44) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL23062820 | 0.83 | SNCA (0.44) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL29612502 | 0.81 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL24668140 | 0.81 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL20987137 | 0.80 | IRAK4 (0.39) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL23042579 | 0.80 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL23042340 | 0.78 | SNCA (0.40) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL20987201 | 0.78 | LPL (0.31) | SNCAIRAK4LPLLIPGEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301357-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| EP-3492462-B1 | AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | SHENZHEN TARGETRX INC (CN) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022187403-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |