Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 9/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23062820 | 0.83 | SNCA (0.44) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL29612564 | 0.80 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL19836331 | 0.80 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL29612502 | 0.79 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL24668140 | 0.79 | SNCA (0.41) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL23042340 | 0.78 | SNCA (0.40) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL29729476 | 0.75 | SNCA (0.38) | SNCAIRAK4IDO1TDO2LPL | |
| SCHEMBL24668910 | 0.73 | NPM1 (0.42) | — | |
| SCHEMBL23061560 | 0.73 | ESR1 (0.36) | — | |
| SCHEMBL18130872 | 0.71 | IRAK4 (0.39) | SNCAIRAK4IDO1TDO2LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528791-B2 | Thyroid hormone receptor beta agonist compounds | TERNS PHARMACEUTICALS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-20240059682-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. | 2024-02-22 | — | — | US | disclosed |
| EP-4301357-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022187403-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| WO-2022187403-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| US-20220281849-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. | 2022-09-08 | — | — | US | disclosed |
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| WO-2021041237-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021041237-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12528791-B2 | Thyroid hormone receptor beta agonist compounds | THRB, THRA, TSHR | SNCA 2690/4885IRAK4 3533/4885IDO1 1866/4885 |
| US-20220281849-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | THRB, THRA, TSHR | SNCA 3065/4885IRAK4 1862/4885IDO1 2264/4885 |
| US-20240059682-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | THRB, THRA, TSHR | SNCA 3199/4885IRAK4 1782/4885IDO1 2485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.