Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.76 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828987 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2NPC1TSHR | |
| SCHEMBL14406221 | 0.81 | ALDH1A1 (0.84) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT | |
| SCHEMBL14406230 | 0.80 | ALDH1A1 (0.80) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT | |
| SCHEMBL15750820 | 0.79 | ALDH1A1 (0.84) | ALDH1A1HPGDSMN1; SMN2NPC1TSHR | |
| SCHEMBL14333125 | 0.78 | ALDH1A1 (0.77) | ALDH1A1HPGDSMN1; SMN2MAPTTSHR | |
| SCHEMBL11890412 | 0.76 | ALDH1A1 (0.71) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT | |
| SCHEMBL5069717 | 0.75 | ALDH1A1 (0.71) | ALDH1A1HPGDSMN1; SMN2NPC1TSHR | |
| SCHEMBL5062856 | 0.73 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT | |
| SCHEMBL14957025 | 0.73 | ALDH1A1 (0.69) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT | |
| SCHEMBL5481730 | 0.73 | ALDH1A1 (0.65) | ALDH1A1HPGDSMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12168057-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2024-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12168057-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ALDH1A1 2776/4885HPGD 3843/4885SMN1; SMN2 2647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.