Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481872 | 0.84 | MAPK14 (0.53) | ALDH1A1HPGDKDM4EMEN1CYP1A2 | |
| SCHEMBL15750820 | 0.81 | ALDH1A1 (0.84) | ALDH1A1HTTHPGDKDM4ECYP1A2 | |
| SCHEMBL4077162 | 0.81 | HTT (0.77) | ALDH1A1HTTHPGDMEN1CYP1A2 | |
| SCHEMBL31117228 | 0.81 | HTT (0.77) | ALDH1A1HTTHPGDMEN1CYP1A2 | |
| SCHEMBL15779107 | 0.81 | HTT (0.57) | ALDH1A1HTTHPGDKDM4EMEN1 | |
| SCHEMBL2557898 | 0.80 | HTT (0.56) | ALDH1A1HTTHPGDKDM4EMEN1 | |
| SCHEMBL10340606 | 0.79 | HTT (0.55) | ALDH1A1HTTHPGDKDM4EMEN1 | |
| SCHEMBL4828987 | 0.79 | ALDH1A1 (1.00) | ALDH1A1HTTHPGDKDM4EMEN1 | |
| SCHEMBL13851240 | 0.77 | HTT (0.53) | ALDH1A1HTTHPGDKDM4EMEN1 | |
| SCHEMBL4078604 | 0.77 | ALDH1A1 (0.60) | ALDH1A1HTTHPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225335-A1 | Pyrazole Derivatives for Treating Condit Ions Mediated by Activation of the Adeno Sine A2B or A3 Receptor | NOVARTIS AG (CH) | 2007-09-27 | — | — | US | disclosed |
| EP-1799206-A2 | PYRAZOLE DERIVATIVES FOR TREATING CONDITIONS MEDIATED BY ACTIVATION OF THE ADENOSINE A2B OR A3 RECEPTOR | Novartis AG (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006015860-A2 | PYRAZOLE DERIVATIVES FOR TREATING CONDITIONS MEDIATED BY ACTIVATION OF THE ADENOSINE A2B OR A3 RECEPTOR | NOVARTIS AG (CH) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225335-A1 | Pyrazole Derivatives for Treating Condit Ions Mediated by Activation of the Adeno Sine A2B or A3 Receptor | ADORA3, ADORA2B, ADORA1 | ALDH1A1 619/4885HTT 3868/4885HPGD 1041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.