Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11938389 | 1.00 | HDAC1 (0.42) | HDAC1AAK1IDO1KDM4EGLA | |
| SCHEMBL1957518 | 0.84 | AAK1 (0.39) | HDAC1AAK1IDO1KDM4EGLA | |
| SCHEMBL29569681 | 0.77 | HDAC1 (0.45) | HDAC1AAK1IDO1KDM4EGLA | |
| SCHEMBL931406 | 0.77 | HDAC1 (0.45) | HDAC1AAK1IDO1KDM4EGLA | |
| SCHEMBL13788857 | 0.75 | ALOX15 (0.38) | IDO1ALDH1A1MEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL16277747 | 0.75 | HDAC1 (0.44) | HDAC1AAK1IDO1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL15158292 | 0.75 | HDAC1 (0.44) | HDAC1AAK1IDO1KDM4EGLA | |
| SCHEMBL10082835 | 0.74 | IDO1 (0.42) | IDO1KDM4EMAPTALDH1A1POLB | |
| SCHEMBL14864698 | 0.73 | SIGMAR1 (0.45) | IDO1KDM4EMAPTALDH1A1POLB | |
| SCHEMBL13036599 | 0.73 | HDAC2 (0.58) | HDAC1KDM4EHDAC2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301357-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-117120051-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022187403-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | TERNS PHARMACEUTICALS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |