Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44782 | 1.00 | KEAP1 (0.53) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL25215053 | 0.82 | HTR2A (0.47) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL31095263 | 0.82 | HTR2A (0.47) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL31095377 | 0.82 | HTR2A (0.43) | HTR2AHTR2CHTR2BUSP30 | |
| SCHEMBL20589417 | 0.82 | HTR2A (0.43) | HTR2AHTR2CHTR2BUSP30 | |
| SCHEMBL4166591 | 0.79 | HTR2A (0.47) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL15976503 | 0.78 | HTR2A (0.47) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL19031388 | 0.78 | HTR2A (0.57) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL31095257 | 0.77 | KEAP1 (0.52) | KEAP1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL25200431 | 0.77 | KEAP1 (0.52) | KEAP1NFE2L2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803963-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-26 | — | — | CN | disclosed |