Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22918743 | 1.00 | CHEK2 (0.52) | CHEK2SLC2A1HDAC1GPR119ALOX5AP | |
| 1,2-Dichloroethane SCHEMBL29709050 | 0.96 | SLC2A1 (0.49) | CHEK2SLC2A1HDAC1GPR119ALOX5AP | |
| SCHEMBL28862478 | 0.89 | ALOX5AP (0.48) | CHEK2SLC2A1HDAC1GPR119ALOX5AP | |
| SCHEMBL6406782 | 0.85 | SLC2A1 (0.58) | CHEK2SLC2A1HDAC1GPR119FAAH | |
| SCHEMBL27158749 | 0.85 | SLC2A1 (0.51) | CHEK2SLC2A1HDAC1GPR119FAAH | |
| SCHEMBL215733 | 0.84 | CHEK2 (0.54) | CHEK2SLC2A1HDAC1GPR119ALOX5AP | |
| SCHEMBL20507845 | 0.84 | GPR119 (0.53) | CHEK2GPR119 | |
| SCHEMBL29615477 | 0.84 | GPR119 (0.53) | CHEK2GPR119 | |
| SCHEMBL26668458 | 0.83 | SLC2A1 (0.59) | CHEK2SLC2A1GPR119 | |
| SCHEMBL3397468 | 0.83 | FAAH (0.50) | CHEK2SLC2A1HDAC1GPR119ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109697-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2026-04-23 | — | — | US | disclosed |
| CN-118955500-A | 4- (Imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2024-11-15 | — | — | CN | disclosed |
| US-20220267320-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2022-08-25 | — | — | US | disclosed |
| EP-4003992-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260109697-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES | CHUK, CNKSR1, KIT | CHEK2 194/4885SLC2A1 4529/4885HDAC1 1344/4885 |
| US-20220267320-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES | NCOA3, NCOR1, NCOA4 | CHEK2 470/4885SLC2A1 3147/4885HDAC1 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.