SCHEMBL29615424

SCHEMBL29615424

Nc1ccc2[nH]c(Cc3cccc(O)c3)nc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.56
GAA P10253 5/20 0.56
PKM P14618 3/20 0.56
KDM4E B2RXH2 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
TSHR P16473 1/20 0.53
RAB9A P51151 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
LMNA P02545 3/20 0.52
NPC1 O15118 2/20 0.52
GRIN1 Q05586 2/20 0.46
GRIN2B Q13224 2/20 0.46
HTT P42858 2/20 0.46
ALDH1A1 P00352 2/20 0.46
EGFR P00533 1/20 0.46
HKDC1 Q2TB90 1/20 0.45
CYP1A2 P05177 1/20 0.45
POLB P06746 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24507643 1.00 MAPT (0.56) MAPTGAAPKMKDM4ETDP1
SCHEMBL3762307 0.84 MAPT (0.76) MAPTGAAPKMKDM4ETDP1
SCHEMBL6233917 0.84 MAPT (0.56) MAPTGAAPKMKDM4ETDP1
SCHEMBL23603266 0.83 GAA (0.69) MAPTGAAPKMTSHRRAB9A
SCHEMBL23793903 0.81 MAPT (0.55) MAPTGAAPKMKDM4ETDP1
SCHEMBL29431250 0.81 PDE5A (0.56) MAPTGAAPKMKDM4ETDP1
SCHEMBL22775734 0.81 PDE5A (0.56) MAPTGAAPKMKDM4ETDP1
SCHEMBL8807641 0.81 SMN1; SMN2 (0.52) MAPTGAAPKMKDM4ETDP1
SCHEMBL22787557 0.77 SMN1; SMN2 (0.52) MAPTGAAPKMKDM4ETSHR
SCHEMBL29613734 0.77 SMN1; SMN2 (0.52) MAPTGAAPKMKDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4259607-A1 BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE TMEM16A LIMITED (GB) 2023-10-18 EP disclosed
CN-116745267-A Benzimidazole derivatives for the treatment of respiratory diseases 跨膜蛋白16A有限公司 2023-09-12 CN disclosed
WO-2022123314-A1 BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE TMEM16A LIMITED (GB) 2022-06-16 WO disclosed