Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762307 | 0.84 | MAPT (0.76) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL29615424 | 0.84 | MAPT (0.56) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL24507643 | 0.84 | MAPT (0.56) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL28777311 | 0.83 | GAA (0.69) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL29725740 | 0.83 | GAA (0.69) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL23793903 | 0.81 | MAPT (0.55) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL8807641 | 0.81 | SMN1; SMN2 (0.52) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL6233351 | 0.79 | RIPK1 (0.61) | MAPTGAAKDM4EPKMTDP1 | |
| SCHEMBL1095852 | 0.78 | ERBB2 (0.53) | EGFRERBB2KITMPO | |
| SCHEMBL1095725 | 0.76 | ERBB2 (0.59) | EGFRERBB2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |