Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31154394 | 0.86 | NPC1 (0.59) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL14714338 | 0.86 | NPC1 (0.59) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL29822900 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1LMNAGAA | |
| SCHEMBL27681975 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1LMNAGAA | |
| SCHEMBL3762307 | 0.81 | MAPT (0.76) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL24507643 | 0.81 | MAPT (0.56) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL29615424 | 0.81 | MAPT (0.56) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL6233917 | 0.81 | MAPT (0.56) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL7916731 | 0.80 | GRIN1 (0.68) | SMN1; SMN2MAPTRAB9ANPC1LMNA | |
| SCHEMBL23793903 | 0.78 | MAPT (0.55) | SMN1; SMN2MAPTRAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775134-A4 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMA CORP (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0775134-A1 | Imidazolin-2-ylaminobenzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004270-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-02-15 | — | — | WO | disclosed |