Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KIF11 | P52732 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RHEB | Q15382 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24507619 | 1.00 | KDM4E (0.61) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14336565 | 0.89 | ALDH1A1 (0.78) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL2361138 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL9620029 | 0.87 | KDM4E (0.80) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL22487928 | 0.84 | SMN1; SMN2 (0.56) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL22648631 | 0.82 | SMN1; SMN2 (0.43) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL1170648 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL13542738 | 0.82 | ALDH1A1 (0.43) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL15625894 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL5032566 | 0.81 | HSP90AA1 (0.53) | KDM4EALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259607-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |