Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14336548 | 0.88 | SMN1; SMN2 (0.73) | SMN1; SMN2TDP1HSP90AA1ESR2ALDH1A1 | |
| SCHEMBL22648631 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2TDP1HSP90AA1ESR2KIF11 | |
| SCHEMBL31695181 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2TDP1HSP90AA1ESR2KIF11 | |
| SCHEMBL2923502 | 0.84 | SMN1; SMN2 (0.78) | SMN1; SMN2TDP1HSP90AA1ESR2ALDH1A1 | |
| SCHEMBL24507619 | 0.84 | KDM4E (0.61) | SMN1; SMN2KIF11ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL29615654 | 0.84 | KDM4E (0.61) | SMN1; SMN2KIF11ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL13542738 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL24602846 | 0.82 | TDP1 (0.47) | SMN1; SMN2TDP1HSP90AA1ESR2KIF11 | |
| SCHEMBL4741168 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2TDP1HSP90AA1ESR2KIF11 | |
| SCHEMBL1106071 | 0.79 | TDP1 (0.76) | SMN1; SMN2TDP1HSP90AA1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132467-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2024-04-25 | — | — | US | disclosed |
| EP-4259607-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132467-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM109, CFTR, TMEM164 | SMN1; SMN2 2486/4885TDP1 4577/4885HSP90AA1 1593/4885 |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | KRAS, NRAS, HRAS | SMN1; SMN2 4018/4885TDP1 4172/4885HSP90AA1 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.