Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003208 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL7003204 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL21501023 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL10288769 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL1207144 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL24737951 | 0.84 | SLC9A1 (0.67) | SLC9A1FFAR1DGAT2L3MBTL1 | |
| SCHEMBL10288351 | 0.83 | CYP4F2 (0.56) | FFAR1ALDH1A1KDM4ECYP4F2CYP4A11 | |
| SCHEMBL2136322 | 0.83 | CYP4F2 (0.56) | FFAR1ALDH1A1KDM4ECYP4F2CYP4A11 | |
| SCHEMBL4780490 | 0.83 | KDM4E (0.54) | SLC9A1FFAR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2776604 | 0.82 | FFAR1 (0.55) | FFAR1SMN1; SMN2CYP4F2CYP4A11L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-10-15 | — | — | US | disclosed |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | SLC9A1 4724/4885FFAR1 3410/4885DGAT2 1992/4885 |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | SLC9A1 4718/4885FFAR1 3294/4885DGAT2 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.