Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22836459 | 1.00 | MAOB (0.47) | MAOBMAOAMAPK1GAAFGFR1 | |
| SCHEMBL29615973 | 0.89 | MAOB (0.45) | MAOBMAOAMAPK1KDM4EALDH1A1 | |
| SCHEMBL22836610 | 0.89 | MAOB (0.45) | MAOBMAOAMAPK1KDM4EALDH1A1 | |
| SCHEMBL24337981 | 0.82 | MAOB (0.47) | MAOBMAOAMAPK1GAAKDM4E | |
| SCHEMBL30174523 | 0.82 | MAOB (0.47) | MAOBMAOAMAPK1GAAKDM4E | |
| SCHEMBL24339233 | 0.77 | MAOA (0.54) | MAOBMAOAGAAKDM4EALDH1A1 | |
| SCHEMBL30174418 | 0.77 | MAOA (0.54) | MAOBMAOAGAAKDM4EALDH1A1 | |
| SCHEMBL22836758 | 0.74 | MAPK1 (0.42) | MAPK1GAAKDM4EALDH1A1GLA | |
| SCHEMBL29616055 | 0.74 | MAPK1 (0.42) | MAPK1GAAKDM4EALDH1A1GLA | |
| SCHEMBL22222273 | 0.73 | MAOB (0.45) | MAOBMAOAMAPK1ALDH1A1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585609-B | 2H-indazole derivatives and their use in the treatment of diseases | 比奥根MA公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-114585609-A | 2H-indazole derivatives and their use in the treatment of diseases | 比奥根MA公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-3990432-A1 | 2H-INDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Biogen MA Inc. (US) | 2022-05-04 | — | — | EP | disclosed |