Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | PRKDC | P78527 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22836132 | 1.00 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL29615935 | 1.00 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL29502511 | 0.96 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL22835309 | 0.96 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL7355696 | 0.81 | ALDH1A1 (0.71) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL27041951 | 0.78 | MAPT (0.48) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL29502284 | 0.78 | ALDH1A1 (0.76) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL1572262 | 0.78 | ALDH1A1 (0.76) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL22835646 | 0.77 | MAPT (0.53) | ALDH1A1MAPTCYP3A4ALOX15PRKDC | |
| SCHEMBL29502581 | 0.77 | MAPT (0.53) | ALDH1A1MAPTCYP3A4ALOX15PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990432-A1 | 2H-INDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Biogen MA Inc. (US) | 2022-05-04 | — | — | EP | disclosed |