Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | PRKDC | P78527 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211200 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL2905188 | 0.82 | PDE5A (0.50) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL29615940 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL22836132 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL2906067 | 0.81 | PDE5A (0.49) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL2902648 | 0.81 | PDE5A (0.49) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL29615935 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL15264824 | 0.79 | KMT2A (0.45) | ALDH1A1KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL20631457 | 0.78 | PDE5A (0.52) | KDM4ECYP3A4PDE5APOLBPDE4B | |
| SCHEMBL22065381 | 0.78 | PDE5A (0.52) | KDM4EMAPTCYP3A4PDE5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |