Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22836448 | 1.00 | MAPK1 (0.43) | MAPK1ROCK1ROCK2CNR1CNR2 | |
| SCHEMBL29616055 | 0.91 | MAPK1 (0.42) | MAPK1ROCK1ROCK2CNR1CNR2 | |
| SCHEMBL22836758 | 0.91 | MAPK1 (0.42) | MAPK1ROCK1ROCK2CNR1CNR2 | |
| SCHEMBL28756695 | 0.78 | IRAK4 (0.55) | KDM4EALDH1A1HPGDIRAK4 | |
| SCHEMBL22836610 | 0.74 | MAOB (0.45) | MAPK1PTGER4KDM4EALDH1A1HPGD | |
| SCHEMBL29615973 | 0.74 | MAOB (0.45) | MAPK1PTGER4KDM4EALDH1A1HPGD | |
| SCHEMBL23529963 | 0.73 | KDM4E (0.51) | MAPK1PTGER4KDM4EALDH1A1HPGD | |
| SCHEMBL20858526 | 0.72 | CHRM2 (0.47) | MAPK1KDM4EALDH1A1HPGDPIK3CA | |
| SCHEMBL22836368 | 0.71 | RXRA (0.51) | MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL29616025 | 0.71 | RXRA (0.51) | MAPK1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585609-B | 2H-indazole derivatives and their use in the treatment of diseases | 比奥根MA公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-114585609-A | 2H-indazole derivatives and their use in the treatment of diseases | 比奥根MA公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-3990432-A1 | 2H-INDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Biogen MA Inc. (US) | 2022-05-04 | — | — | EP | disclosed |