Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | EIF4A1 | P60842 | 3/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590321 | 1.00 | DHODH (0.70) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL25118630 | 0.90 | DHODH (0.57) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL29617653 | 0.90 | DHODH (0.69) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL23590251 | 0.90 | DHODH (0.69) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL23590075 | 0.89 | DHODH (0.71) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL26073767 | 0.89 | DHODH (0.56) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL29617671 | 0.85 | PLA2G2A (0.82) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL23590067 | 0.85 | PLA2G2A (0.82) | DHODHALDH1A1GAAPLA2G2AMEN1 | |
| SCHEMBL23590236 | 0.85 | DHODH (0.53) | DHODHALDH1A1EIF4A1PTGESALOX5 | |
| SCHEMBL26073753 | 0.85 | DHODH (0.89) | DHODHALDH1A1GAAPLA2G2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4438042-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2024-10-02 | — | — | EP | disclosed |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-09-05 | — | — | US | disclosed |
| EP-3793562-B1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-19 | — | — | EP | disclosed |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-04 | — | — | US | disclosed |
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2022-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 72/4885GAA 533/4885 |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 64/4885GAA 497/4885 |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 64/4885GAA 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.