Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641751 | 1.00 | HPGD (0.53) | HPGDTP53GLARXFP1MEN1 | |
| SCHEMBL17339636 | 0.85 | HPGD (0.74) | HPGDTP53GLAMEN1KMT2A | |
| SCHEMBL28239400 | 0.82 | HPGD (0.56) | HPGDTP53GLARXFP1MEN1 | |
| SCHEMBL17339512 | 0.82 | HPGD (0.55) | HPGDTP53GLARXFP1MEN1 | |
| SCHEMBL5785228 | 0.82 | HPGD (0.67) | HPGDTP53GLAMEN1KMT2A | |
| SCHEMBL17339443 | 0.81 | HPGD (0.63) | HPGDTP53GLARXFP1MEN1 | |
| SCHEMBL29617795 | 0.81 | LMNA (0.62) | HPGDALDH1A1LMNAPPARA | |
| SCHEMBL17339437 | 0.81 | LMNA (0.62) | HPGDALDH1A1LMNAPPARA | |
| SCHEMBL17339241 | 0.81 | HPGD (0.53) | HPGDTP53GLAMEN1KMT2A | |
| SCHEMBL17339271 | 0.81 | AKR1B1 (0.54) | HPGDTP53GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |