Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339437 | 1.00 | LMNA (0.62) | LMNADNMT3APPARAHDAC1HDAC6 | |
| SCHEMBL17339271 | 0.90 | AKR1B1 (0.54) | LMNADNMT3APPARAHPGDALDH1A1 | |
| SCHEMBL23657593 | 0.90 | LMNA (0.72) | LMNADNMT3APPARAHDAC1HDAC6 | |
| SCHEMBL17339512 | 0.88 | HPGD (0.55) | PPARAHPGDALDH1A1 | |
| SCHEMBL11516368 | 0.87 | LMNA (0.68) | LMNADNMT3APPARAHDAC1HDAC6 | |
| SCHEMBL29471048 | 0.85 | PTGER4 (0.54) | LMNAPPARAHPGDALDH1A1 | |
| SCHEMBL17339505 | 0.85 | PTGER4 (0.54) | LMNAPPARAHPGDALDH1A1 | |
| SCHEMBL11356211 | 0.84 | LMNA (0.64) | LMNADNMT3APPARAHDAC1HDAC6 | |
| SCHEMBL11464602 | 0.84 | PTGER4 (0.69) | LMNADNMT3APPARAHDAC1HDAC6 | |
| SCHEMBL11706059 | 0.83 | DNMT3A (0.72) | LMNADNMT3APPARAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |