Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 4/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339470 | 1.00 | APEX1 (0.50) | APEX1TRPV1HPGDTP53GLA | |
| SCHEMBL18641946 | 0.89 | HPGD (0.54) | APEX1TRPV1HPGDTP53GLA | |
| SCHEMBL17339342 | 0.85 | APEX1 (0.58) | APEX1TRPV1HPGDTP53GLA | |
| SCHEMBL17339485 | 0.85 | CTSS (0.51) | APEX1TRPV1HPGDTP53GLA | |
| SCHEMBL17339519 | 0.83 | TRPV1 (0.52) | APEX1TRPV1ALDH1A1LMNAHTT | |
| SCHEMBL17339267 | 0.83 | TRPV1 (0.58) | APEX1TRPV1HPGDALDH1A1LMNA | |
| SCHEMBL17339460 | 0.83 | HPGD (0.56) | APEX1TRPV1HPGDTP53GLA | |
| SCHEMBL17339413 | 0.81 | ALDH1A1 (0.47) | TRPV1HPGDTP53GLAEGFR | |
| SCHEMBL12697369 | 0.80 | KMT2A (0.62) | APEX1HPGDTP53GLAALDH1A1 | |
| SCHEMBL17339636 | 0.80 | HPGD (0.74) | TRPV1HPGDTP53GLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116303-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | Loxo Oncology, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |