Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21245930 | 0.81 | TYK2 (0.42) | DYRK1ATYK2PKMRAB9AMAPT | |
| SCHEMBL23583166 | 0.77 | TYK2 (0.35) | DYRK1ATYK2PKMKMT2A | |
| SCHEMBL21227320 | 0.77 | TYK2 (0.35) | DYRK1ATYK2PKMGAA | |
| SCHEMBL126525 | 0.75 | DYRK1A (0.46) | DYRK1APKMRAB9AMAPTGAA | |
| SCHEMBL29618341 | 0.75 | DYRK1A (0.46) | DYRK1APKMRAB9AMAPTGAA | |
| SCHEMBL21333142 | 0.71 | DYRK1A (0.35) | DYRK1APKMRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL21935993 | 0.71 | DYRK1A (0.35) | DYRK1APKMRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15435737 | 0.71 | DYRK1A (0.39) | DYRK1APKMRAB9AMAPTGAA | |
| SCHEMBL30848471 | 0.71 | DYRK1A (0.35) | DYRK1APKMRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL25768673 | 0.71 | DYRK1A (0.35) | DYRK1APKMRAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |