Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 6/20 | 0.52 |
| ▸ | PRKCA | P17252 | 5/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 5/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PRKCH | P24723 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618359 | 1.00 | ACVR1 (0.54) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618431 | 0.91 | ACVR1 (0.58) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618396 | 0.88 | CCNA2 (0.65) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618397 | 0.88 | CCNA2 (0.65) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL23245920 | 0.87 | KCNH2 (0.47) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618365 | 0.87 | KCNH2 (0.47) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618440 | 0.86 | ABL1 (0.60) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29618389 | 0.85 | ACVR1 (0.57) | ACVR1ABL1PRKCAPRKCDEGFR | |
| SCHEMBL29883957 | 0.84 | LMNA (0.51) | CDK2AURKACDK9AURKBKCNH2 | |
| SCHEMBL29618422 | 0.83 | JAK2 (0.62) | ACVR1ABL1PRKCAPRKCDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502555-A | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amines for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |