Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | STK4 | Q13043 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.43 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23245925 | 1.00 | MAPT (0.50) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL23245955 | 0.89 | DGAT1 (0.50) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL29618345 | 0.89 | DGAT1 (0.50) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL23245914 | 0.82 | RAB9A (0.60) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL29618414 | 0.81 | RAB9A (0.58) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL23245938 | 0.81 | RAB9A (0.58) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL29618450 | 0.80 | SYK (0.53) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL23245953 | 0.80 | SYK (0.53) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL23246065 | 0.79 | UBE2T (0.59) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL29618429 | 0.79 | UBE2T (0.59) | MAPTKDM4EALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502555-B | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amine for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| EP-4045506-A1 | DERIVATIVES OF 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-N-(PYRIDIN-3-YL) PYRIMIDIN-2- AMINE FOR TREATING PROLIFERATIVE DISEASES AND CONDITIONS | Aucentra Therapeutics Pty Ltd (AU) | 2022-08-24 | — | — | EP | disclosed |
| CN-114502555-A | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amines for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |